Titration for ADHD Medications The most effective treatment for ADHD is a stimulant medication however, determining the appropriate dosage requires adjustment. The goal is to create an optimal therapeutic effect, minimizing side effects. The dosage of ADHD stimulants is largely determined by the individual's medical history and metabolic variations instead of height or weight. During titration your doctor may gradually increase the dosage over time in order to find the "target dose" that e...