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Figure 1 Quite a few divergent techniques from the CNS are involved in the pathophysiology of depression. The pathophysiological systems within the CNS that herbal antidepressants are proposed to act on include monoamine neurotransmissions, the HPA axis, neurotrophins, and synapse variety and performance as proven. Dysfunction of such techniques results in amplified incidence of depression. Correspondingly, antidepressant discovery initiatives toward these systems have furnished numerous pharmac...

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